TY - JOUR AU - Jinan Fadhil Mahdi, PY - 2020/09/20 Y2 - 2024/03/29 TI - Laplace Transform based Prediction of Drug Concentration in Blood JF - مجلة المستنصرية للعلوم والتربية JA - Mustansiriyah.J.Sci.Edu VL - 17 IS - 5 SE - DO - UR - https://edumag.uomustansiriyah.edu.iq/index.php/mjse/article/view/50 SP - 89-98 AB - <p>Performance of an oral dosage form like tablet or capsule is<br>determined by the amount of drug present in the plasma at a given time.<br>Prediction of this in-vivo performance in terms of concentration of drug in<br>blood poses problems. A new technique called convolution which is based<br>on system approach is presented with actual data and details of<br>implementation of the convolution technique. This technique is of great<br>relevance in advanced dosage forms having longer duration of performance<br>like 12, 16 or 24 hours. In the design and development of oral products this<br>technique allows for prediction of the plasma profile without conducting<br>bio studied in human subjects that highly expensive and time consuming.</p> ER -