Laplace Transform based Prediction of Drug Concentration in Blood
Keywords:concentration of drug in blood, convolution technique, absorption of drug, Convolution Integral
Performance of an oral dosage form like tablet or capsule is
determined by the amount of drug present in the plasma at a given time.
Prediction of this in-vivo performance in terms of concentration of drug in
blood poses problems. A new technique called convolution which is based
on system approach is presented with actual data and details of
implementation of the convolution technique. This technique is of great
relevance in advanced dosage forms having longer duration of performance
like 12, 16 or 24 hours. In the design and development of oral products this
technique allows for prediction of the plasma profile without conducting
bio studied in human subjects that highly expensive and time consuming.